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Convenience 146, 319 ; . It seems likely that, in many countries, some individuals would find a new male contraceptive method would meet their needs. Moreover, there is an increasing awareness that men should share, to a greater extent, responsibility for contraception 320 ; . Recent surveys of attitudes of men and women regarding the use of novel hormonal male methods have confirmed this suggestion 3, 321 ; . More than 400 men and women of reproductive age were asked about their current methods of contraception and whether they thought they or their partners would use a new method of male contraception. The centers sampled were in countries with a high contraceptive prevalence. There were large differences among the centers in the types of contraception used. For example, oral contraception was used by 41% of couples in Edinburgh compared with 0% in Shanghai, where the intrauterine device was used by 62%. Despite these differences, there was significant support for a male hormonal method, and 44 83% of men surveyed would use a male pill if it were available Table 3 ; . In separate survey in the same centers, women were asked what they thought about the use of a male hormonal method 321 ; . One third or more of women who currently had a partner, in all centers except that in Hong Kong, said that they would use a hormonal male method now, and more than 70% of women in Shanghai and Edinburgh and white women in South Africa indicated that they would use it in the future Table 3 ; . It interesting that the acceptability was lowest among both men and women in Hong Kong, where condoms are the commonest current method. These studies suggest that male hormonal contraception would be acceptable to many couples and support the findings of a randomized telephone survey of 1005 Americans aged 18 yr or more. More than 70% of both men and women agreed that men should play a greater role in using contraception, and 45% of women thought that men would take a male pill 322 ; . Approval of a hypothetical method of contraception is unlikely to be an accurate measure of the actual use in practice when a method is marketed. However, these surveys confirm that a hormonal method would be attractive to a proportion of contraceptive users, for example, zelnorm 2007. Novartis besitzt innerhalb der pharmazeutischen Industrie eine der produktivsten Pipelines in spter Entwicklungsphase. Nach wichtigen Zulassungsgenehmigungen hat das Unternehmen 2007 einige neue Medikamente auf den Markt gebracht und dabei bedeutende Erfolge erzielt. Der voll gefllte Plan zur Einfhrung neuer Produkte und die soliden Wachstumsprognosen fr das strategische Gesundheitsportfolio des Konzerns werden voraussichtlich das mittelfristige Wachstum bis 2010 und darber hinaus sttzen. Novartis drfte damit fr weitere Jahresergebnisse in Rekordhhe gut positioniert sein. Der ausgesetzte Verkauf von Ezlnorm und die Generikakonkurrenz fr Lotrel und Lamisil in den USA werden den Nettoumsatz der Division Pharmaceuticals auch im weiteren Verlauf des Jahres beeintrchtigen. Der Nettojahresumsatz dieser Produkte belief sich 2006 auf USD 2, 5 Milliarden. Novartis hat deshalb die Umsatzprognosen fr das Gesamtjahr revidiert. Demzufolge wird auf Konzernebene fr die fortzufhrenden Geschftsbereiche ein Nettoumsatzwachstum im mittleren einstelligen Prozentbereich und fr die Division Pharmaceuticals ein Nettoumsatzwachstum im unteren einstelligen Prozentbereich erwartet jeweils in Lokalwhrungen ; . Um die Einfhrung neuer Produkte zu frdern und die Initiativen zur Produktivittssteigerung zu beschleunigen, wird die Division Pharmaceuticals 2007 weitere Ressourcen umverteilen. Neben diesen Initiativen verfolgt Novartis weitere Strategien fr eine anhaltend starke Performance der brigen Divisionen. Infolgedessen bekrftigt Novartis die Erwartung, dass die fortzufhrenden Geschftsbereiche auch 2007 Rekordwerte beim operativen Ergebnis und beim Reingewinn erzielen werden and tibolone. Christian et al." refers to Dr. Samuel Christian and his associates at the University of Alabama in Birmingham's Neurosciences Program; in 1975 they identified DMT, 5-methoxy-DMT, 5-methoxy-N, N-DMT, Nmethyltryptamine and tryptamine in human cerebrospinal fluid In May 1977, Dr. Wolfgang Vogel of the Jefferson Medical College in Philadelphia isolated 5-methoxy-DMT in brain tissue; the Christian team also found DMT there. If DMT and 5-methoxy-DMT are neurotransmitters, as many researchers think, then an excess of them may be a cause of schizophrenia. Observing dramatic increases of DMT in the spinal fluid of animals and humans "during extreme stress, " Dr. Christian hypothesized that the tendency among some people to develop mental aberrations might reflect "a genetic predisposition to excessive DMT production as a response to stress." Later work, reported by L Corbert, Christian and others in the British journal of Psychiatry 1978, 132: 139-144 ; , indicated that schizophrenics do not have higher levels of DMT in their brains than control subjects. Research in this intriguing area.

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