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SorbitrateRequirements can be described as a set of constraints that need to be solved. The concept of constraints takes a high importance in the practical application of the content negotiation. In this context, we define a constraint as: "an atomic requirement that belongs to the environment in which the final delivered content will be used". In practice, the architecture can take into account the constraints collection of more than one element. In our approach, the resolution strategy starts from the assumption that the original content is accepted and continues by adding the constraints progressively. Finally, it ends with a solution that determines the content to be delivered. Possible solutions include an empty content in the case where the constraints can not be solved. In this case, the server sends a negative reply to the client. In order to achieve an efficient content negotiation solution, the environment constraints must be well expressed in order to reflect the picture of the delivery context. Constraints syntax must: 1- Provide enough expressiveness, in order to allow the description of what is required. 2- Offer an easy analysis for resolution strategies. 3- Avoid ambiguity: constraints must result in a unique solution. Example: Let's assume that we have in the server side an original content in the form of XML document written in English. Let's have the two following constraints expressed in the natural language: C1 , C2 . situation where the global context is represented by the first constraint C1, the content of the server can be delivered directly to the client. This case is equivalent to having no constraints at all. In a situation where we have C2 as environment constraint, the original content can't be delivered directly to the client because the content doesn't respect the environment constraints. In our approach, the client constraints that depend on capabilities are extracted directly from the HardwarePlatform, SoftwarePlatform and BrowserUA components from the UPS client profiles. In the RDF bags: OnlySupportedResources, PreferredSupportedResource and NonSupportedResources, we extract additional constraints related to the content in terms of capabilities and preferences. During the negotiation matching, the client profile and the document instance profile of the requested content are parsed and the set of included constraints are stored in memory according to their types. The server makes the reference to the document instance profile. According to its content, the server can retrieve using the exchange protocol- the client resource profile [11] that corresponds to the resource used by the requested content. For example, the server retrieves the. In this issue: BioCrossroads names Johnson President and CEO Recent BioCrossroads media coverage Meeusen continues role with BioCrossroads Endocyte secures funding IU gets ready to kick off Life Sciences Week Purdue Professor confirmed as Director of National Science Foundation New initiative designed to promote participation in the federal SBIR STTR program Voice from the Industry: Bioanalytical System Inc's Pete Kissinger Lilly Provides Financial Support and Medicines for Tsunami Relief in Southeast Asia Recently passed bill eases worries about industry university collaborations Cook Inc. and IU develop innovative internship program Ball State University nanotechnology researcher named distinguished professor Suros unveils new breast biopsy tools ICVA conference attraction efforts pay off News of Note Other academic news Other industry news Johnson's commitment, previous experience with effort crucial in decision The Board of Directors of BioCrossroads, Indiana's life sciences initiative, didn't have to look far when seeking a successor to departing CEO Charles Schalliol. 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