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ARE INSOMNIA PATIENTS PATHOLOGICALLY WORRIED OR SIMPLY WORRIED ABOUT SLEEP? Carney CE, 1 Edinger JD, 2, 1 Krystal AD, 1 Stepanski EJ, 3 Kirby A1 1 ; Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA, 2 ; Psychology Service, Durham Veteran's Affairs Medical Center, Durham, NC, USA, 3 ; Rush University Medical Center, Chicago, IL, USA Introduction : People with insomnia have been described as dispositionally anxious and worried; although these studies have not examined carefully identified diagnostic insomnia subtypes. Methods : To assess for insomnia and rule-out other sleep disorders, participants completed the Duke Structured Interview for Sleep Disorders DSID ; , 2 weeks of sleep logs, and 2 nights of polysomnography. The Structured Clinical Interview for DSM-IV Axis I Disorders SCID ; was used to assess for mental disorders; the Dysfunctional Beliefs and Attitudes about Sleep Scale DBAS-16 ; Sleep Worry subscale assessed worry about sleep; the Penn State Worry Questionnaire PSWQ ; assessed general worry; and the Beck Anxiety Inventory BAI ; assessed general anxiety. Two groups were formed based on diagnosis: Primary Insomnia PI; N 58 ; and Insomnia related to Mental Disorder IMD; N 20 ; . Results : A multivariate analysis of variance MANOVA ; tested whether PI and IMD differed on BAI, PSWQ, or Sleep Worry. ANOVAs followedup a significant MANOVA, and revealed higher anxiety and worry in the IMD group; there were no significant differences on Sleep Worry. A MANOVA on BAI items revealed that items typical of Panic Disorder e.g., heart pounding, lose control ; discriminated PI from IMD. A MANOVA on PSWQ items revealed that discriminating items related to Generalized Anxiety Disorder diagnostic criteria: namely, worry frequency, controllability and pervasiveness. Conclusion : Unlike the IMD group, the PI group was not characterized by pathological worry and anxiety e.g., scores above the clinical cutoff ; . Moreover, there were no group differences on sleep-specific worry. Together the findings suggest that it is inaccurate to consider those with PI as a necessarily pathologically worried or anxious group; rather, their worry pertains to sleep. Support optional ; : National Sleep Foundation Pickwick Fellowship; Classifying Psychiatric, Medical, and Primary Insomnias NIH R01, MH067057 and ketamine.
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PEIA is providing some generic antibiotics without copay to its members Antibiotics during January and February, in an effort to convince them to use generic Drug Name Cost per medications. See related story on page 1. Course of Therapy The list on the right provides information on the costs, to PEIA, of a range of antibiotics. We encourage providers to consult the list and to prescribe the PENICILLINS GEOCILLIN $198.29 least expensive drug which the provider feels will provide satisfactory theraAUGMENTIN $71.05 peutic value to the patient. DICLOXACILLIN $10.42 During the recent anthrax threat, for example, many people were seeking AMOXIL BID $10.06 prescriptions of Cipro. Treatment would consist of 60 days of Cipro 500, at a DYNAPEN $8.02 cost of $524.34 The generic drug, Doxycycline is widely held to be the equal AMOXICILLIN $6.50 of Cipro in treating anthrax, and costs approximately $30 for POLYMOX TRIMOX $5.39 a similar course of therapy. AMOXIL $5.17 In short, the same number of tax dollars which will treat17 AMPICILLIN $4.75 PRINCIPEN $4.46 people with the generic, will treat only one with the brand AMCILL $3.62 name medication. BEEPEN VEETIDS $2.98 The list printed below shows PEIA's costs for various OMNIPEN $2.38 antihypertensive medications. In many cases providers will PENICILLIN VK $2.38 have a choice of medications to treat a given illness. We ask that, where appropriate, providers choose the less expensive alternative. CEPHALOSPORINS LORABID $93.11 ACE INHIBITORS CEFTIN $81.40 Drug Name Formulary Status Net PEIA Cost Day KEFLEX $74.22 Captopril Yes $0.41 VANTIN $70.89 Enalapril Yes $0.70 CEFZIL $65.87 Mavik No $0.72 LORABID SUSP $62.19 Lotensin Yes $0.81 CECLOR CD $59.65 Univasc No $0.82 Prinivil Yes $0.83 CEDAX $58.57 Monopril No $0.94 SUPRAX $56.43 Zestril No $0.94 CEFACLOR ER $55.01 Aceon No $0.95 CEFTIN SUSP $49.00 Accupril Yes $0.99 OMNICEF $47.65 Altace Yes $1.10 KEFTAB $43.17 Vasotec No $1.37 CEFADROXIL $40.46 Capoten Yes $2.32 DURICEF $35.26 VELOSEF $23.48 ANGIOTENSIN II RECEPTOR BLOCKERS CEFACLOR $22.44 Drug Name Formulary Status Net PEIA Cost Day CEPHALEXIN $9.63 Atacand No $1.16 Micardis Yes $1.18 QUINOLONES Diovan Yes $1.22 FLOXIN $88.26 Teveten No $1.23 CIPRO $67.02 Avapro No $1.27 NOROXIN $64.64 Cozaar Yes $1.29 LEVAQUIN $64.55 Hyaaar Yes $1.29 ZAGAM $62.54 Micardia HCT Yes $1.29 AVELOX $62.38 Diovan HCT Yes $1.30 TEQUIN $56.60 Atacand HCT No $1.42 CIPRO CYSTITIS $15.58 Avalide No $1.47.
14 tablets 28 tablets 56 tablets 90 tablets 98 tablets Polyamide aluminium PVC blisters 28 x 1 tablets Polyamide aluminium PVC perforated unit dose blisters Not all package sizes may be marketed 6.6 Instructions for use and handling.
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Independent prescribing by pharmacists and nurses in Wales was given the go-ahead by the Welsh Assembly Government last week. As will be the case in England and Scotland, suitably trained pharmacists in Wales will be able to prescribe any licensed medicine for any condition, with the exception of Controlled Drugs. During a visit to Boots The Chemists in Cardiff last week, health minister Brian Gibbons announced that a project board will be set up to advise and support the implementation of independent prescribing in Wales. "Independent prescribing will mean that suitably qualified nurses and pharmacists will not only be able to offer advice on health promotion and management of chronic conditions but also be able to prescribe independently for their patients in hospital and community settings. This will provide new ways for patients to access the right person, at the right time to provide the most appropriate service, " said Dr Gibbons. The British Medical Association welcomed the announcement, in contrast to its response to the launch of independent prescribing in England and Scotland last year PJ, pendently. "Many [patients with] minor selflimiting illnesses or ailments [who] do not really need to see a GP, could be seen and treated quite appropriately by this new extended role. With the introduction of cheaper, and finally free prescriptions, the request for those medicines that would otherwise have needed a visit to the GP to obtain the prescription, could be obtained from, for example, the pharmacist, and release a valuable GP appointment for someone who truly needed it." Peter Jones, chairman of the Welsh Executive of the Royal Pharmaceutical Society, said that the move is good news for patients, pharmacy and the wider health care community in Wales, allowing pharmacists' skills and expertise to benefit patients. Peter Haydn Jones, chief executive of Community Pharmacy Wales, also welcomed the announcement. "CPW looks forward to participating in and working with the project board in order to see this key policy delivered across Wales." The Welsh Assembly Government cannot yet confirm when pharmacists in Wales are likely to begin prescribing independently, for example, hyzaar tabs.
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The mechanism of preventing migraine is unknown; earlier theories that these drugs act by preventing vasodilatation have not been confirmed in laboratory and clinical studies.
Antiepileptic Drug Use and Pregnancy - January 2001 by Mark S. Yerby M.D. 2000, 2001 North Pacific Epilepsy Research Center - seazures.
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